Companies to test new drugs designed to fight many kinds of cancer

By Gina Kolata

The New York Times

For the first time ever, three pharmaceutical companies are poised to test whether new drugs can work against a wide range of cancers independently of where they originated - breast, prostate, liver, lung. The drugs go after an aberration involving a cancer gene fundamental to tumor growth. Many scientists see this as the beginning of a new genetic age in cancer research.

Great uncertainties remain, but such drugs could mean new treatments for rare, neglected cancers, as well as common ones. Merck, Roche and Sanofi are racing to develop their own versions of a drug they hope will restore a mechanism that normally makes badly damaged cells self-destruct and could potentially be used against half of all cancers.

No pharmaceutical company has ever conducted a major clinical trial of a drug in patients who have different kinds of cancer, researchers and federal regulators say.

"This is a taste of the future in cancer drug development," said Dr. Otis Webb Brawley, the chief medical and scientific officer of the American Cancer Society. "I expect the organ from which the cancer came from will be less important in the future and the molecular target more important," he added.

And this has major implications for cancer philanthropy, experts say. Advocacy groups should shift from fundraising for particular cancers to pushing for research aimed at many kinds of cancer at once, Brawley said.

At the heart of this search for new cancer drugs are patients like Joe Bellino, who was a post office clerk until his cancer made him too sick to work.

Seven years ago, he went into the hospital for hernia surgery, only to learn he had liposarcoma, a rare cancer of fat cells. A large tumor was wrapped around a cord that connects the testicles to the abdomen. "I was shocked," he said in an interview this summer.

Companies have long ignored liposarcoma, seeing no market for drugs to treat a cancer that strikes so few. But it is ideal for testing Sanofi's drug because the tumors nearly always have the exact genetic problem the drug was meant to attack - a fusion of two large proteins.

If the drug works, it should bring these raging cancers to a halt. Then Sanofi would test the drug on a broad range of cancers with a similar genetic alteration. But if the drug fails against liposarcoma, Sanofi will reluctantly admit defeat.

"For us, this is a go/no-go situation," said Laurent Debussche, a Sanofi scientist who leads the company's research on the drug.

Health authorities in the United States and Europe worried that the medicines might have unexpected effects.

"Drugs of this type had never been given to a human being," Dr. Gwen Nichols of Roche said. The studies looked only at safety, but Nichols said there were encouraging hints that the drugs might be working. In biopsies and scans, cancer cells appeared to be dying.

Rigorous efficacy studies are next. If they are successful, they will be followed by clinical trials across cancer types.

Recently, Merck began its study to find a safe dose. It is enrolling only patients with acute myelogenous leukemia.

Once the company finds the best dose, it plans to give its drug to just 15 to 30 patients and look for efficacy. And if the drug fails to do its job?

"Then we will not bring the drug forward," Gilliland said.

Sanofi is in much the same position. It just started safety tests in Europe. Medical centers in the United States will be added next year. Like Merck, it will focus solely on patients who are most likely to respond to its own drug - in this case, patients with liposarcoma like Bellino.

Bellino said over the summer that he hoped to be among the first to try a new drug that could combat liposarcoma. When the call goes out for study subjects, he said, "I will be waving my hands."

But the test will come too late for him. He died from his cancer Nov. 13.

a new era

No pharmaceutical company has ever conducted a major clinical trial of a drug in patients who have different kinds of cancer, both researchers and federal regulators say.

Source: http://www.lef.org/news/LefDailyNews.htm?NewsID=17897&Section=Disease

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