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Tuesday, June 25, 2013
Addiction relapse might be thwarted by turning off brain trigger
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Public release date: 24-Jun-2013[ | E-mail |
Share ] Contact: Jeffrey Norris
jeff.norris@ucsf.edu
415-502-6397
University of California - San Francisco
UCSF study points to potential strategy for erasing memory of addiction
A new study by researchers at the Ernest Gallo Clinic and Research Center at UC San Francisco offers encouraging findings that researchers hope may one day lead to a treatment option for people who suffer from alcohol abuse disorders and other addictions.
In the study, conducted in rats, the UCSF researchers were able to identify and deactivate a brain pathway linked to the memories that cause cravings for alcohol, thus preventing the animals from seeking alcohol and drinking it, the equivalent of relapse.
"One of the main causes of relapse is craving, triggered by the memory by certain cues - like going into a bar, or the smell or taste of alcohol," said lead author Segev Barak, PhD, at the time a postdoctoral fellow in the lab of co-senior author Dorit Ron, PhD, a Gallo Center investigator and UCSF professor of neurology.
"We learned that when rats were exposed to the smell or taste of alcohol there was a small window of opportunity to target the area of the brain that reconsolidates the memory of the craving for alcohol and to weaken or even erase the memory, and thus the craving" he said.
The study, also supervised by co-senior author Patricia H. Janak, a Gallo Center investigator and UCSF professor of neurology, will be published online on June 23, 2013 in Nature Neuroscience.
In the first phase of the study, rats had the choice to freely drink water or alcohol over the course of seven weeks, and during this time developed a high preference for alcohol. In the next phase, they had the opportunity to access alcohol for one hour a day, which they learned to do by pressing a lever. They were then put through a 10-day period of abstinence from alcohol.
Following this period, the animals were exposed for 5 minutes to just the smell and taste of alcohol, which cued them to remember how much they liked drinking it. The researchers then scanned the animals' brains, and identified the neural mechanism responsible for the reactivation of the memory of the alcohol - a molecular pathway mediated by an enzyme known as mammalian target of rapamycin complex 1 (mTORC1).
They found that just a small drop of alcohol presented to the rats turned on the mTORC1 pathway specifically in a select region of the amygdala, a structure linked to emotional reactions and withdrawal from alcohol, and cortical regions involved in memory processing.
They further showed that once mTORC1 was activated, the alcohol-memory stabilized (reconsolidated) and the rats relapsed on the following days, meaning in this case, that they started again to push the lever to dispense more alcohol.
"The smell and taste of alcohol were such strong cues that we could target the memory specifically without impacting other memories, such as a craving for sugar," said Barak, who added that the Ron research group has been doing brain studies for many years and has never seen such a robust and specific activation in the brain.
In the next part of the study, the researchers set out to see if they could prevent the reconsolidation of the memory of alcohol by inhibiting mTORC1, thus preventing relapse. When mTORC1 was inactivated using a drug called rapamycin, administered immediately after the exposure to the cue (smell, taste), there was no relapse to alcohol-seeking the next day. Strikingly, drinking remained suppressed for up to 14 days, the end point of the study. These results suggest that rapamycin erased the memory of alcohol for a long period, said Ron.
The authors said the study is an important first step, but that more research is needed to determine how mTORC1 contributes to alcohol memory reconsolidation and whether turning off mTORC1 with rapamycin would prevent relapse for more than two weeks.
The authors also said it would be interesting to test if rapamycin, an FDA-approved drug currently used to prevent organ rejection after transplantation, or other mTORC1 inhibitors that are currently being developed in pharmaceutical companies, would prevent relapse in human alcoholics.
"One of the main problems in alcohol abuse disorders is relapse, and current treatment options are very limited." Barak said. "Even after detoxification and a period of rehabilitation, 70 to 80 percent of patients will relapse in the first several years. It is really thrilling that we were able to completely erase the memory of alcohol and prevent relapse in these animals. This could be a revolution in treatment approaches for addiction, in terms of erasing unwanted memories and thereby manipulating the brain triggers that are so problematic for people with addictions."
###
The other co-authors of the paper are Feng Liu, PhD, Sami Ben Hamida, PhD, Quinn V. Yowell BS, Jeremie Neasta, PhD, and Viktor Kharazia, PhD, all of the Gallo Center and UCSF Department of Neurology.
The study was supported by funds from the National Institute on Alcohol Abuse and Alcoholism and funds from the State of California for Medical Research on Alcohol and Substance Abuse administered through UC San Francisco.
The UCSF-affiliated Ernest Gallo Clinic and Research Center is one of the world's preeminent academic centers for the study of the biological basis of alcohol and substance use disorders. Gallo Center discoveries of potential molecular targets for the development of therapeutic medications are extended through preclinical and proof-of-concept clinical studies.
UCSF is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 24-Jun-2013[ | E-mail |
Share ] Contact: Jeffrey Norris
jeff.norris@ucsf.edu
415-502-6397
University of California - San Francisco
UCSF study points to potential strategy for erasing memory of addiction
A new study by researchers at the Ernest Gallo Clinic and Research Center at UC San Francisco offers encouraging findings that researchers hope may one day lead to a treatment option for people who suffer from alcohol abuse disorders and other addictions.
In the study, conducted in rats, the UCSF researchers were able to identify and deactivate a brain pathway linked to the memories that cause cravings for alcohol, thus preventing the animals from seeking alcohol and drinking it, the equivalent of relapse.
"One of the main causes of relapse is craving, triggered by the memory by certain cues - like going into a bar, or the smell or taste of alcohol," said lead author Segev Barak, PhD, at the time a postdoctoral fellow in the lab of co-senior author Dorit Ron, PhD, a Gallo Center investigator and UCSF professor of neurology.
"We learned that when rats were exposed to the smell or taste of alcohol there was a small window of opportunity to target the area of the brain that reconsolidates the memory of the craving for alcohol and to weaken or even erase the memory, and thus the craving" he said.
The study, also supervised by co-senior author Patricia H. Janak, a Gallo Center investigator and UCSF professor of neurology, will be published online on June 23, 2013 in Nature Neuroscience.
In the first phase of the study, rats had the choice to freely drink water or alcohol over the course of seven weeks, and during this time developed a high preference for alcohol. In the next phase, they had the opportunity to access alcohol for one hour a day, which they learned to do by pressing a lever. They were then put through a 10-day period of abstinence from alcohol.
Following this period, the animals were exposed for 5 minutes to just the smell and taste of alcohol, which cued them to remember how much they liked drinking it. The researchers then scanned the animals' brains, and identified the neural mechanism responsible for the reactivation of the memory of the alcohol - a molecular pathway mediated by an enzyme known as mammalian target of rapamycin complex 1 (mTORC1).
They found that just a small drop of alcohol presented to the rats turned on the mTORC1 pathway specifically in a select region of the amygdala, a structure linked to emotional reactions and withdrawal from alcohol, and cortical regions involved in memory processing.
They further showed that once mTORC1 was activated, the alcohol-memory stabilized (reconsolidated) and the rats relapsed on the following days, meaning in this case, that they started again to push the lever to dispense more alcohol.
"The smell and taste of alcohol were such strong cues that we could target the memory specifically without impacting other memories, such as a craving for sugar," said Barak, who added that the Ron research group has been doing brain studies for many years and has never seen such a robust and specific activation in the brain.
In the next part of the study, the researchers set out to see if they could prevent the reconsolidation of the memory of alcohol by inhibiting mTORC1, thus preventing relapse. When mTORC1 was inactivated using a drug called rapamycin, administered immediately after the exposure to the cue (smell, taste), there was no relapse to alcohol-seeking the next day. Strikingly, drinking remained suppressed for up to 14 days, the end point of the study. These results suggest that rapamycin erased the memory of alcohol for a long period, said Ron.
The authors said the study is an important first step, but that more research is needed to determine how mTORC1 contributes to alcohol memory reconsolidation and whether turning off mTORC1 with rapamycin would prevent relapse for more than two weeks.
The authors also said it would be interesting to test if rapamycin, an FDA-approved drug currently used to prevent organ rejection after transplantation, or other mTORC1 inhibitors that are currently being developed in pharmaceutical companies, would prevent relapse in human alcoholics.
"One of the main problems in alcohol abuse disorders is relapse, and current treatment options are very limited." Barak said. "Even after detoxification and a period of rehabilitation, 70 to 80 percent of patients will relapse in the first several years. It is really thrilling that we were able to completely erase the memory of alcohol and prevent relapse in these animals. This could be a revolution in treatment approaches for addiction, in terms of erasing unwanted memories and thereby manipulating the brain triggers that are so problematic for people with addictions."
###
The other co-authors of the paper are Feng Liu, PhD, Sami Ben Hamida, PhD, Quinn V. Yowell BS, Jeremie Neasta, PhD, and Viktor Kharazia, PhD, all of the Gallo Center and UCSF Department of Neurology.
The study was supported by funds from the National Institute on Alcohol Abuse and Alcoholism and funds from the State of California for Medical Research on Alcohol and Substance Abuse administered through UC San Francisco.
The UCSF-affiliated Ernest Gallo Clinic and Research Center is one of the world's preeminent academic centers for the study of the biological basis of alcohol and substance use disorders. Gallo Center discoveries of potential molecular targets for the development of therapeutic medications are extended through preclinical and proof-of-concept clinical studies.
UCSF is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2013-06/uoc--arm062413.php
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Monday, June 24, 2013
Everything you want to know about Android's new Navigation Drawer
Google's Android developers have delivered a great video all about the new Navigation Drawer
We've talked before about how the Android team is serious about design. They want Android, and the great apps that developers create, to not only work well, but to look good. We noticed this at Google I/O in May, that there was a new (and long-awaited) focus on building applications that look like the belong. Apps with a consistent and elegant user interface, versus the jumble of different design styles and choices of the past.
It's a big undertaking. You have to account for different screen sizes, devices with or without the recommended button layout, and most of all you need to find a fluid look and feel that works well for the end user. Nobody likes an app that is difficult to use. Google tried to get everyone on-board with the action bar method, and it's a great solution for some things. But sometimes, you need to get dirty and have a list of user choices and options. That's where the new Navigation Drawer concept comes into play.
Grab your phone. Open the YouTube app or Google Play Books app. Swipe your finger to the right on the main screen (view). That's the new Navigation Drawer at work. Google Play Books could probably get away with just an action bar and overflow area (those three dots in the upper right) but the YouTube app has plenty of choices and options that would otherwise be buried three levels deep. The Navigation Drawer seems like a perfect way to present them all to the users -- you and me.
A lot of thought went into this, and luckily the Android developers are willing to share their thoughts about it all. Join Roman Nurik, Jens Nagel and Rich Fulcher after the break for 47 minutes of great information about why, where and when you would want to use the Navigation Drawer. Even if you're never going to design an Android app, it's a great watch and really drives the idea home.
Source: Android Developers YouTube
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Source: http://feedproxy.google.com/~r/androidcentral/~3/7hk2K-numJE/story01.htm
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On a technicality, Hong Kong and China extradite themselves from Snowden
The case of NSA leaker Edward Snowden was one that neither Hong Kong nor Beijing wanted to get involved in. With a stalling maneuver, Hong Kong let Mr. Snowden flee US extradition.
A giant screen at a Hong Kong shopping mall shows Edward Snowden, the former contractor accused of leaking information about NSA surveillance programs. He left Hong Kong on Sunday.
Vincent Yu/AP
EnlargeBy allowing Edward Snowden to leave Hong Kong Sunday, hours after the United States sought to extradite him, the government there has rid itself ? and Beijing ? of an awkward diplomatic and legal problem.
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Peter Ford is The Christian Science Monitor?s Beijing Bureau Chief. He covers news and features throughout China and also makes reporting trips to Japan and the Korean peninsula.
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Indeed there are strong suspicions in the former British colony that the Hong Kong authorities deliberately gave the fugitive NSA whistleblower time to get out.
The US extradition request, filed on Saturday, ?did not fully comply with the legal requirements under Hong Kong law,? the Hong Kong government said on Sunday, so it had asked Washington for ?additional information.?
In the meantime, there was ?no legal basis to restrict Mr. Snowden from leaving Hong Kong,? the statement added. On Sunday morning, Snowden boarded a plane bound for Moscow, accompanied by legal advisors from the anti-secrecy group Wikileaks according to a post on the group?s Twitter account.
His final destination was unclear.
?I suspect it was ?wink, wink, nudge, nudge, you?ve got 48 hours to get out of Dodge City?,? says Kevin Egan, a Hong Kong lawyer with experience of extradition cases. ?When the government got the clarification it had sought, it might not have been able to let him go.?
?Snowden managed to get away because Hong Kong decided to stall,? adds Claudia Mo, a lawmaker with the pro-democracy Civic Party. ?The matter was too tricky for Sino-American relations ? so Beijing gave instructions he should be given time to leave.?
Snowden had said he planned to challenge any US extradition attempt in Hong Kong courts, declaring his faith in the city?s rule of law. But he faced the possibility of having to stay in jail throughout the court proceedings, which could have taken several years according to local lawyers.
His case was a thorny one for Beijing, anxious to improve relations with the United States and embarrassed by the US fugitive?s presence in Hong Kong, but unable to intervene openly in Hong Kong?s judicial process under the ?one country, two systems? principle that safeguards Hong Kong?s courts.
Hong Kong?s top official, Chief Executive Leung Chun-ying had promised that the case would be handled ?in accordance with the laws and established procedures of Hong Kong.? But the politically sensitive case ?would have been quite a test for our rule of law,? says Ms. Mo. ?It would have been a very thorny issue and it is all for the best for both Hong Kong and Beijing that he has gone.?
?This was not a case that Hong Kong or Beijing ever wanted to get involved in,? agrees Mr. Egan. ?The best thing for both of them was for Snowden to leave.??
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Common Cases Where A Unsecured Loan is Critical - John Black
June 24th, 2013 at 1:32 am
There almost certainly is a requirement for yourself to have yourself a guarantor in submitting an application for a cash loan. A guarantor is someone who will take all the obligation for the loan you applied together if in case you fail to pay up. You must select a guarantor that has an impressive credit score and salary that?s sufficiently good to handle the loan. Men are often stunned to hear the good news from the money lenders that they are able to utilize their cars as a collateral just to get qualified. If you are caring for your auto loan, there?s a better opportunity that you may lend money instead of your car title loan. These financing options are usually not ideal, but they?re greater than pawnshops and payday loans. You have to keep in your thoughts and understand clearly that you may forfeit your precious automobile if you neglect to pay back the loans you made. That can prevent you from getting to and fro the office and earning a salary, and your wages are exactly what you want to get away from debt. Fast cash loans are generally personal loan determined by when you acquire your salary. People from all over the world face numerous financial problems everyday and often, short-term borrowing is not that possible. If you will be searching for a means to fix such matters, why don?t you go for quick cash by having a secured loan or instant cash? Besides, this is the fastest option to receive the fast money you need in spite of your bad credit score or when your pals and family cannot help you monetarily. During your application procedure of the loan don?t ignore to look into the conditions and terms of loans, know all the possible costs you will include specifically those covered charges. There are a lot of means that may cause you to extra charges on these loans however the blame certainly falls into you, that is why knowing all the details of a loan is best!
Source: http://www.son.web.id/business-products-services/common-cases-where-a-unsecured-loan-is-critical/
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Sunday, June 23, 2013
Kerry: Political solution urgently needed in Syria
DOHA, Qatar (AP) ? U.S. Secretary of State John Kerry called on Saturday for an urgent political resolution to the war in Syria, saying that unless the bloodshed stops, the region could descend into a chaotic sectarian conflict.
Kerry met in Doha with 10 of his counterparts from Arab and European nations to coordinate aid to the embattled rebels trying to oust Syrian President Bashar Assad in a two-year civil war that has left 93,000 dead. All the nations in attendance agreed to step up aid to the rebels, Kerry said.
While he offered no specifics, Kerry said the assistance would help change the balance on the battlefield, where regime forces have scored recent victories. Kerry blamed Assad for the deteriorating situation in Syria, saying that while the international community was attempting to hold a conference to set up a transitional government, Assad invited Iranian and Hezbollah fighters to bolster his troops.
It was Kerry's first meeting with his counterparts about aid to the Syrian rebels since President Barack Obama announced that the U.S. would send lethal aid to the opposition despite concern that weapons could fall into the hands of Islamic extremists in Syria. That decision was partly based on a U.S. intelligence assessment that Assad had used chemical weapons, but Kerry expressed deeper concern about Iran and Hezbollah fighters.
"That is a very, very dangerous development," Kerry said. "Hezbollah is a proxy for Iran. ... Hezbollah in addition to that is a terrorist organization."
Kerry blamed Hezbollah and Assad with thwarting efforts to diffuse sectarian rebels and to negotiate a settlement.
"We're looking at a very dangerous situation," that had transformed "into a much more volatile, potentially explosive situation that could involve the entire region," Kerry said.
The war already has spilled into neighboring countries and is increasingly being fought along sectarian lines, pitting Sunni against Shiite Muslims and threatening the stability of Syria's neighbors.
Kerry met with his counterparts in the Qatari capital on the first stop of a seven-nation trip through the Mideast and Asia where he is tackling difficult foreign policy issues ? from finding peace between the Israelis and Palestinians to trying to gain traction on U.S. talks with the Taliban to end the Afghanistan war. James Dobbins, U.S. special envoy to Afghanistan and Pakistan, arrived in Doha on Saturday, but talks with the Taliban have not been scheduled.
Kerry seemed to put the ball in the Taliban's court, saying the Americans and Qataris were all on board to help negotiate a political resolution to the war and it was up to the Taliban to come to the table at a new political office they opened last week in Doha. "We are waiting to find out whether the Taliban will respond, Kerry said.
"We will see if we can get back on track. I don't know whether that's possible or not," Kerry said. "If there is not a decision made by the Taliban to move forward in short order, then we may have to consider whether the office has to be closed."
On Syria, Kerry has been pressing hard on Russia to back an international conference intended to end the bloodshed in Syria and allow a transitional government to move the country beyond civil war.
Russia has been the key ally of Assad's regime throughout the two-year conflict.
Top U.S. diplomats are ready to go to Geneva to meet with Russian Foreign Minister Sergey Lavrov and other officials next week to advance the political process, Kerry said. The date and location of the international conference on Syria haven't been announced, but it's already being dubbed "Geneva 2" because a similar event was held there a year ago.
On Friday, Russia's foreign minister said Washington was sending contradictory signals on Syria that could derail an international conference intended to end that country's civil war, warning that U.S. talk about a possible no-fly zone would only encourage the rebels to keep fighting.
Sergey Lavrov also criticized demands that Assad step down. Russian leaders warn that if Assad steps aside, the resulting power vacuum could be quickly filled by al-Qaida connected rebels, who are well-armed and aggressive.
Source: http://news.yahoo.com/kerry-political-solution-urgently-needed-syria-154043827.html
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